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Beyond impairments in cavernosal relaxation, ROS accumulation and oxidative stress linked to AGE formation promote reductions in antioxidant responses, lipid peroxidation, DNA damage, and oxidative protein modifications [37,38]

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Conversely, intraventricular administration of the iron chelator DFO improves striatal pathology and motor phenotypes in R6/2 HD mice (Chen et al., 2013)